Thanks guys. Lost is getting super-interesting in season 5
Heroes is not up there but its still decent comic book fun... I love time travel concept and so I find both Heroes and Lost quite interesting.
How I met your Mother
Psych (don't miss it for anything in the world)
Californication (must watch under any circumstances)
The Mentalist (A Psych rip-off but with a serious look)
Entourage (currently watching it myself)
The Office (Steve Carell, need I say more? )