Continuously rising medicines cost-- Why ?

alekhkhanna said:
Dude, pleeeeeease. No. Not enough. There's a reason we do 4 phases of human studies after animal trials. Phase 1 and 2 will look at dose ranging, efficacy and safety signals (pertaining to planned dose) before going to RCTs for phase 3.
If someone needs 40 mg of Olmesartan, 20 mg will not do. Their BP will not be controlled.
Please don't do this.
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Bro he was arguing that generics work. I was saying it works cause while standard dosage might be 100mg, someone young might only need 50mg due to immunity or lower intensity problems. Hence while it might appear to work, anecdotal incidences dont mean they will work for everyone.
 
Party Monger said:
Bro he was arguing that generics work. I was saying it works cause while standard dosage might be 100mg, someone young might only need 50mg due to immunity or lower intensity problems. Hence while it might appear to work, anecdotal incidences dont mean they will work for everyone.
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Young means? Peadiatric dosing are different.
Immunity leads to lower dosing? Huh? Thats not correct.
Whats a lower intensity problem?
And I'm not saying generics don't work. 90% of what you see in markets is generics - branded generics (like Calpol, Crocin etc). JA is unbranded generic. And overall QC is substandard, more with JA meds.
 
alekhkhanna said:
Young means? Peadiatric dosing are different.
Immunity leads to lower dosing? Huh? Thats not correct.
Whats a lower intensity problem?
And I'm not saying generics don't work. 90% of what you see in markets is generics - branded generics (like Calpol, Crocin etc). JA is unbranded generic. And overall QC is substandard, more with JA meds.
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Man for some ADULTS the intensity of the disease is low due to better immunity.
So drugs with even lower quantatity of active ingredient than indicated on the label, the drug work and person can get healed. I dont know whats so hard to understand about this? This is for those people who are saying they took the drugs with lower actual quantity than indicated on the label and still got healed.

Doctors change or increase the dosage depending on the response too. IF it wasnt the case then everyone would get the same dosage everytime and we wouldnt have multiple weight variants of the same drug. I dont know why you want to drag this on. Im saying the same thing. generics suck unless its tested and there are lab reports confirming atleast the quantiy of the active ingredient if not the bioavailbility.
 
Party Monger said:
Man for some ADULTS the intensity of the disease is low due to better immunity.
So drugs with even lower quantatity of active ingredient than indicated on the label, the drug work and person can get healed. I dont know whats so hard to understand about this? This is for those people who are saying they took the drugs with lower actual quantity than indicated on the label and still got healed.

Doctors change or increase the dosage depending on the response too. IF it wasnt the case then everyone would get the same dosage everytime and we wouldnt have multiple weight variants of the same drug. I dont know why you want to drag this on. Im saying the same thing. generics suck unless its tested and there are lab reports confirming atleast the quantiy of the active ingredient if not the bioavailbility.
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The first part is incorrect wrt drugs and dosing. Dose is according to weight, yes, becuase every drug undergoes body distribution, which impacts bioavailibility, metabolism, effect and excretion. So weight based dosing segregation almost always happens for certain drugs like antibiotics.
The intensity of disease in some cases can determine the dosing as well (again, antibiotics being the most common example), but if the API is lesser than indicated, either the patient may not recover or will develop resistant bacteria. Weight based dosing with correct frequency ensure either all the organisms are killed by the drug or further multiplication is stopped.
 
alekhkhanna said:
The first part is incorrect wrt drugs and dosing. Dose is according to weight, yes, becuase every drug undergoes body distribution, which impacts bioavailibility, metabolism, effect and excretion. So weight based dosing segregation almost always happens for certain drugs like antibiotics.
The intensity of disease in some cases can determine the dosing as well (again, antibiotics being the most common example), but if the API is lesser than indicated, either the patient may not recover or will develop resistant bacteria. Weight based dosing with correct frequency ensure either all the organisms are killed by the drug or further multiplication is stopped.
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Man you contradict yourself in your own reply. You keep on going when I'm not even disagreeing with you lmao.
 
Party Monger said:
Man for some ADULTS the intensity of the disease is low due to better immunity.
So drugs with even lower quantatity of active ingredient than indicated on the label, the drug work and person can get healed. I dont know whats so hard to understand about this? This is for those people who are saying they took the drugs with lower actual quantity than indicated on the label and still got healed.

Doctors change or increase the dosage depending on the response too. IF it wasnt the case then everyone would get the same dosage everytime and we wouldnt have multiple weight variants of the same drug. I dont know why you want to drag this on. Im saying the same thing. generics suck unless its tested and there are lab reports confirming atleast the quantiy of the active ingredient if not the bioavailbility.
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not true. Doses are not changed based on the response, doing so can be counterproductive in many situations. Drug dose adjustments are based on a plethora of things that cannot be explained here.
 
Party Monger said:
ITs like talking to a wall, arguments devoid and ignorant of context. Red the god damn chain of replies.
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Don't worry, now a days, your might've seen 'professionals' using google for their own clarify while deciding things. So, an example:
www.nursingtimes.net

How to calculate drug doses and infusion rates accurately | Nursing Times

Abstract Nurses need to be confident in calculating drug doses to safety administer medicines to patients as prescribed. This article provides essential
www.nursingtimes.net www.nursingtimes.net

What you said can be verified at: https://en.wikipedia.org/wiki/Dose_(biochemistry)

Now, not advocating for such usage, one must follow an expert's advice, but can also be cognizant of what is going on. Blindly trusting claimed experts is also an issue sometimes.
 
TEUser2K1 said:
Don't worry, now a days, your might've seen 'professionals' using google for their own clarify while deciding things. So, an example:
www.nursingtimes.net

How to calculate drug doses and infusion rates accurately | Nursing Times

Abstract Nurses need to be confident in calculating drug doses to safety administer medicines to patients as prescribed. This article provides essential
www.nursingtimes.net www.nursingtimes.net

What you said can be verified at: https://en.wikipedia.org/wiki/Dose_(biochemistry)

Now, not advocating for such usage, one must follow an expert's advice, but can also be cognizant of what is going on. Blindly trusting claimed experts is also an issue sometimes.
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Who qualifies as an expert? Yes we have apps for calculating drug infusion doses, pump flow rates etc. but all these are useless without a clinicians involvement.
 
Look, I am fine with the concerns shown by you all with the rising cost of medicines.

Could someone explain why in the heck does Vicks vaporub cost 100 bucks for the small jar, and Vicks Inhaler costs 60 bucks?

The only answer is that these pharmaceutical companies are increasing their profits at the cost of our ill health.
 
thomasjude47 said:
Who qualifies as an expert? Yes we have apps for calculating drug infusion doses, pump flow rates etc. but all these are useless without a clinicians involvement.
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Earlier been involved in this sector in one way or other, have seen environment where people in position embellish innocent, naive, hapless patients without any regard and respect towards human life. Not everyone are like that, but with all due respect, these days one needs to be bit self aware and cautious of situations if one can afford to.
atg666 said:
The only answer is that these pharmaceutical companies are increasing their profits at the cost of our ill health.
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As you say, some of those involved in one of the most innate asset of human life - their health, happens to be driven solely by greed. Unlike old times, people are not guided by principles, ethos, ethics, dharma, karma, etc. So, here we are.
 
TEUser2K1 said:
Earlier been involved in this sector in one way or other, have seen environment where people in position embellish innocent, naive, hapless patients without any regard and respect towards human life. Not everyone are like that, but with all due respect, these days one needs to be bit self aware and cautious of situations if one can afford to.

As you say, some of those involved in one of the most innate asset of human life - their health, happens to be driven solely by greed. Unlike old times, people are not guided by principles, ethos, ethics, dharma, karma, etc. So, here we are.
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I'm a pretty old graduate, so it does not apply during my time, but if you look for the past 10-15 years, the cost of doing MBBS, PG and super specialisation is around 4-7 CR. The govt colleges cannot fulfill the quantum of doctors needed for Indian patients. Most medical colleges are private and run by politically connected people - and the entrance + fees is mind boggling. It is a rubbish systemm. But you can imagine if anyone spends that amount of money, ethics go for a toss. Even for those who study from govt centers, the allure of money is enticing - add to it hospitals now being run by MBAs with targets for doctors (surgeries, referrels etc), patients indeed are sent for a ride.
So yeah, definitely do your own research but also be safe from quacks and places offering things super cheap.
 
atg666 said:
Look, I am fine with the concerns shown by you all with the rising cost of medicines.

Could someone explain why in the heck does Vicks vaporub cost 100 bucks for the small jar, and Vicks Inhaler costs 60 bucks?

The only answer is that these pharmaceutical companies are increasing their profits at the cost of our ill health.
Click to expand...
www.thehindu.com

Electoral Bonds: Many pharma companies that bought electoral bonds faced regulatory actions

Top pharmaceutical companies purchased electoral bonds amidst regulatory scrutiny, including Hetero, MSN, Divi's, Intas, Lupin, Mankind, Micro Labs, and Natco.
www.thehindu.com www.thehindu.com

1. Get investigated for drug quality
2. Pay electoral bond
3. Investigation closed
4. ???
5. Profit!
 
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kiran6680 said:
www.thehindu.com

Electoral Bonds: Many pharma companies that bought electoral bonds faced regulatory actions

Top pharmaceutical companies purchased electoral bonds amidst regulatory scrutiny, including Hetero, MSN, Divi's, Intas, Lupin, Mankind, Micro Labs, and Natco.
www.thehindu.com www.thehindu.com

1. Get investigated for drug quality
2. Pay electoral bond
3. Investigation closed
4. ???
5. Profit!
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this is the main issue & narrative set by Opposition Party that every thing can be done via Money, if so why they themselves accepted those bonds?
 
Emperor said:
this is the main issue & narrative set by Opposition Party that every thing can be done via Money, if so why they themselves accepted those bonds?
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1. Get accused of crime (true or false)
2. Pay bribe to get off
3. Pay a bit to a beggar on the street
4. ???
5. Profit (and the beggar is also corrupt now)
 
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