Yes, AFAIK you would need different drivers for different chipsets. But that should be pretty simple - its mostly either the integrated nVidia or Via SATA drivers, rarely would it be an additional 3rd party controller on your motherboard.
Unless you suffer from upgraditis and upgrade regularly, your config will remain the same , so integrate the relevant drivers for your system. A year or so later, should you upgrade and your chipset changes, no harm in making a new slip-streamed CD!