Strange issue regarding non-usability of mouse

hello, i am facing this wiered issue with windows xp pro 64-bit edition. everything goes fine till fresh installation. after installation, when i update my motherboard drivers(using inf updates for intel mobo), the drivers get installed asking for reboot. after re-booting, my USB mouse dosent response.
I tried to install all other updates before installation of inf updates, the mouse worked. but the moment i install inf updates, my mouse becomes unusable. any idea as to why is it happening.

Btw, i am using windows xp professional corporate edition 64-bit. I also found that after the updating of the inf files, none of my usb drivers(pen drives) are working...
 
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