This is my completely personal anecdote, no solid medical evidence to back up the claim.
I started having pain in my wrists some years earlier when typing. I researched on alternative keyboard layouts, and moved to Dvorak layout.
Dvorak Simplified Keyboard - Wikipedia, the free encyclopedia
The Dvorak Keyboard -- a Primer
The premise of Dvorak layout is that your fingers have to move around less as the most frequently used letters are on the home row. My understanding is that the standard QWERTY layout is based on the old typewriter layout, which was designed to reduce chances of striking 2 subsequent keys from same row, causing a key jam.
QWERTY - Wikipedia, the free encyclopedia
Since I moved to Dvorak layout, I haven't had any wrist pain till now.
The bad:
It took me some months to come to my previous speed with the old QWERTY layout.
It seems my brain cannot hold 2 layouts simultaneously; I cannot touch-type with the standard QWERTY keyboard now; have to 'hunt&peck' via sight. I seen people online who claim to be equally proficient with both layouts, but didn't work that way for me.
Intially, there is some cognitive dissonance because the alphabet on keyboard is different from the one that appears on the screen. Over time, the cognitive dissonance fades away. In the beginning, I re-arranged the keys on the keyboard to match the DVORAK layout, but its too cumbersome to do this everytime I got a new keyboard.
PS, this is probably useless if you 'hunt&peck' with QWERTY rather than 'touch-type'.