I assume that you are talking about the laptop WiFi, then yes, its better to keep it turned off if you do not need it. The power consumption is negligible, but if it gives an additional few minutes, who cares.
On Routers : Mine is powered down at night thru the Advanced setting in DD WRT. During daytime, there is usually one device connected via WiFi, so I leave it on.
The power saving is minimal and not worth looking at. Security : use MAC filtering along with a good password. As far as life is concerned, heat is the biggest enemy - so if its cool then not an issue. Spectrum crowding - I dont think its that big an issue, unless you live in extremely crowded areas.