As per my previous post i would recommend :
Vx450
Lite-on 20x Sata
APC 650VA
KB+Mouse
CM690
Seagate 500GB
2GB Ram
Abit iP35
SP2208WFP
Radeon 3650 /Quadro FX 560
Proc - Q6600/E8400
Total - approx 57600
Speakers + Soundcard can cost anything from 250 to 25000 as per your wish, but IMO forget the soundcard for now, get a basic set of speakers/ good HP's and splurge when you are flush again
Potential Compromises
Get generic KB+Mouse for 250 each - save 1000
Get Zebronics Bijli instead of CM690 - save around 1500
Get E228WFP instead of the SP - save 1500
Get a APC 500VA UPS - save 1500
Get a E7200(2.5Ghz) proccy, save 3000-4000
So depending on the compromises you can save up to 10000 adn use that for speakers/soundcard/more ram
A year down you can add a TRUE heatsink and OC the processor to 3-3.5 Ghz
Well, thats about all that i can contribute, so i'll sign off by saying good luck with your purchase - whatever it may turn out to be