as such a single antispyware cant be considered a complete security solution.
i use
Javacool Spyware Blaster (its not an active antispyware which removes infection but kind of a preventive software)
Spybot Search and Destroy
Ad-Aware SE Personal
in addition you need a good firewall and a good antivirus software.
i use Comodo Personal firewall and NOD32(its a paid software) while in free av progs you can use AVG / AVAST / ANTIVIR PE.
i have heard that microsoft antispywear is also good but i have not used it. there are many othere utilities too which i may have missed but i have been fairly satisfied with these software set.