That's the whole problem. The Architecture of Inactivated SARS-CoV-2 with Postfusion Spikes doesn't elicit any immun- response even in in-vitro studies.
That was the basic problem in developing an effective vaccine against covid like Rabies etc.
That's why it's such a safe vaccine...it doesn't elicit anything in vivo!!
I must go into little technicalities here. This ham handed approach may sound very simple and easy specially with so many pre existing BPL inactivation approach.
1. BPL only disassemble S1 protein of spike from S2 protein ( only observed in older strains..NOT A SINGLE STUDY HAS BEEN DONE WITH ANY SINGLE POINT MUTANT VARIANT...NONE!!)
2. Cryoelectron tomography and subtomogram are the only way to ascertain the disassembly. And averaging of these spikes yielding a density map that closely matches the overall structure of the SARS-CoV postfusion spike and its corresponding glycosylation sites in human is the only conclusive proof that this vaccine is even capable of producing any immune response.
Where exactly Bharat Biotech is publishing these extremely crucial things?
And this is only asking the first two most basic questions...if they can satisfy with their explanation, it's just the beginning.
These things are not difficult at all and doesn't even touch the crazy science of immunity. This is just very basic microbiology and I'm not a microbiologist. But we do have microbiologists...some good ones, who actually demonstrated us the mechanism of action of the vaccines available. Even they couldn't decipher how Covaxin works.
I will be more than happy to dig way deeper this Sunday. But nobody has any answers, but there are thousands of unanswered questions.
MOA of Covishield is far more difficult, but as it was kind of an open source project, anyone can look up what has been done with that vaccine ( it's even more weird involving a very little understood extremely scary virus)
Only the mRNA vaccines are non scary and very easy to understand.
Disclaimer: I'm not an anti vaxxer and have taken 2 doses of a vaccine months ago. I'm not an expert in immunolgy or vaccine development.
But as a doctor of public health, I have full right to ask questions about vaccines and may suggest one vaccine over another (only because I don't understand how it works, not because one is superior/ inferior over another)
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