And where are studies to confirm anti spike antibody is protective in nature? In case of doing a meaningless humoral antibody response, if they really collected the data of 552 HCWs could have followed them after 8-12 weeks and did a study on how many of them got infected under similar exposure in covishield and covaxin arm and could calculate the p value ( to see if these vaccines have any significant protective value or not!!?? Of course they won't, and nobody would publish the paper...they could have then attach another study on disease severity along this vaccinated population with high exposure history Vs non vaccinated with lower chance of exposure, calculate the same predictive value..which possibly could show some protective value of these vaccines..now it would have been published)
The internet is flooded with meaningless studies, I get raw data of hundreds of such studies for statistical calculations emailed to me on a daily basis from everywhere ( this is very common in medical field, we medical statistics people help friends/ colleagues direct/ indirect.. just with the calculations)
The latest trend is to measure antibody titre and trying to correlate it with vaccinations. However no one bothers to check antibody titre with recovered cases these days ( as few did those and there were absolutely no relationship between spike antibody titre and clinical recovery, many recovered with titre less than 1, many succumbed with very high titre...what does this mean? Pretty simple...spike antibody is useless to predict outcome...there's nothing new in it...same happened with influenza, avian flu etc.etc.)
I couldn't find article which deals with the proper MOA of Covaxin. Even finding the constituents of the same was very difficult.
Sputnik and mRNA vaccines may end up ineffective, but at least a common person can understand how they planned it to work.