Possibly, but keeping the corners proper will be a PITA. And you've to cut out for the "N" at the bottom. If more than 1 person is getting the Nook HD+, get one of those 3-guard pack from AMZ/Ebay and you can split the cost. I got the XtremeShield for around 1100 (pack of 3) from GEB. Specifically went for it due to good reviews and a glossy finish (matte makes the colors wash out, which is no fun while reading comics).
Nice. You're good to go then. Check the XDA thread for Nook HD/HD+. Specifically, check for Leapinlar's thread. He outlines some cool flashes for Nook HD+, from rooting (temp/perma CWM) to only enabling the "Install from external sources" (which is not present in stock fimrware).
I highly recommend rooting (and enabling external sources) otherwise the Nook HD+ will RESET itself if you try browsing/modifying any file in the SYSTEM folder. Plus helps in sideloading apps/games not available for Nook HD+.